Antigen Stability Controls Antigen Presentation
نویسندگان
چکیده
منابع مشابه
Antigen presentation
The immune response to infection depends centrally on the T lymphocytes of the immune system, and the detection of infection by T lymphocytes depends in turn on the presentation of antigen to the T cells by molecules encoded in the major histocompatibility complex (MHC). The biological function of these molecules is to bind proteolytic fragments (peptides) derived from foreign proteins generate...
متن کاملBCR ubiquitination controls BCR-mediated antigen processing and presentation.
BCR-mediated antigen processing occurs at immunologically relevant antigen concentrations and hinges on the trafficking of antigen-BCR (Ag-BCR) complexes to class II-containing multivesicular bodies (MVBs) termed MIICs. However, the molecular mechanism underlying the trafficking of Ag-BCR complexes to and within MIICs is not well understood. In contrast, the trafficking of the epidermal growth ...
متن کاملImmune Activation and Antigen Presentation
Matthew D. Griffin1, Nianzeng Xing1,3, and Rajiv Kumar1,2 1Department of Internal Medicine, Division of Nephrology, and 2Department of Biochemistry and Molecular Biology and Mayo Proteomics Research Center, Mayo Clinic and Foundation, Rochester, Minnesota 55905; email: [email protected]; [email protected]; [email protected] 3Current address: Department of Urology, Beijing Chao Yang Ho...
متن کاملAutophagy-assisted antigen cross-presentation
It is generally believed that most tumor antigens are passively released from either health or dying tumor cells as intact soluble antigens, peptide fragments complexed with heat shock proteins (HSPs), or packaged in secretary vesicles in the form of microparticles or exosomes. The passive release of tumor antigens is generally non-inflammatory and non-immunogenic; however, results from others ...
متن کاملEndothelial Cell-Mediated Antigen Presentation*
Immune recognition of endothelial cells (ECs) has been implicated in a number of vascular diseases. Although ECs have been shown to stimulate T lymphocytes in vitro, these conditions were not physiological, and it remained unclear what occurred in vivo. Antigen presentation by ECs in vivo was tested using transgenic mice that express a protein antigen (β-galactosidase, β-gal) exclusively in the...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2004
ISSN: 0021-9258
DOI: 10.1074/jbc.m405738200